9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner
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چکیده
منابع مشابه
Is Sudden Hearing Loss Associated with Atherosclerosis?
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متن کاملANRIL expression is associated with atherosclerosis risk at chromosome 9p21.
OBJECTIVE We tested the hypothesis that expression of transcripts adjacent to the chromosome 9p21 (Chr9p21) locus of coronary artery disease was affected by the genotype at this locus and associated with atherosclerosis risk. METHODS AND RESULTS We replicated the locus for coronary artery disease (P=0.007; OR=1.28) and other manifestations of atherosclerosis such as carotid plaque (P=0.003; O...
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Background: Common carotid intima-media thickness (CC-IMT) measured by ultrasonography as a non-invasive method is nowadays known as a marker for early atherosclerosis. Objectives: Survey the relationship between serum uric acid and carotid intima-media thickness considering hypertension. Materials and Methods: This study was designed as a comparative cross-sectional study in northern Ira...
متن کاملCoronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.
BACKGROUND Genome-wide association studies have recently identified a locus on chromosome 9p21 that influences risk of coronary artery disease (CAD). The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD). METHODS AND RESULTS We genotyped 2277 individuals, age 24...
متن کاملThe chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease.
AIMS we tested the hypothesis that the 9p21 risk locus promotes atherosclerosis by examining the association between rs10757278 and coronary artery disease (CAD) severity and progression determined by semi-quantitative angiographic scores. METHODS AND RESULTS the rs10757278 single nucleotide polymorphism (SNP) was genotyped as the marker for the 9p21 locus in 2334 Caucasian patients undergoin...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2016
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370216636718